What is PEA? PEA is an amide of palmitic acid, a saturated fatty acid, which acts as an endogenous agonist of the endocannabinoid receptor. PEA is considered a food ingredient that can be isolated from soybeans, peanuts and egg yolk, but PEA is also known to be produced naturally in mammalian tissues. PEA is produced as a biological response and repair mechanism, potentiating its actions on cannabinoid CB1, CB2 and GPR55 receptors and TRPV11 channels. Given PEA's agonist action on endocannabinoid receptors, it is used to treat joint pain and sports inflammation, but may also contribute to relaxation and tranquillity leading to good quality sleep. Numerous preclinical studies have demonstrated the ability of PEA to reduce inflammation and pain induced by various acute stimuli. This anti-inflammatory and analgesic action of PEA is dose-dependent and has been confirmed in models of chronic inflammation and chronic or neuropathic pain. In these models, chronic treatment with PEA produced the following actions: Preserved peripheral nerve morphology. It reduced endoneural oedema. Decreased mast cell activation. Reduced the production of proinflammatory mediators in the lesion. Product name Food supplement based on palmitoylethanolamide. Directions for use Recommended daily dose: 1 capsule. Take 1 capsule at any time of the day, try to repeat daily around the same time. Flavours Neutral Warnings Food supplements should not be used as a substitute for a balanced diet. Do not exceed the expressly recommended daily dose. Keep out of the reach of young children. A varied and balanced diet and a healthy lifestyle are important.